Effect of MRD negativity and factors associated with not achieving MRD negativity. (A) Kaplan-Meier curve of OS in all patients with NPM1 mutant, by PC2 PB MRD status. (B) CIR in all patients with NPM1 mutant, by PC2 PB MRD status. (C) Volcano plot of univariable associations with not achieving MRD negativity. The HR for age is per 10 years, and WCC and platelets are log-transformed. (D) Multivariable logistic regression of factors associated with not achieving MRD negativity. The HR for age is per 10 years, and WCC and platelets are log-transformed. ∗Cytogenetic risk is with normal karyotype as the reference group. ^NPM1 mutation type is with type A as the reference group.