Effect of combination of FLT3-ITD and DNMT3A. (A) Rates of remission, PC2 MRD negativity, and relapse from MRD^– state, by FLT3-ITD and DNMT3A mutation status. (B) Kaplan-Meier curve of OS in all patients with NPM1 mutant, by FLT3-ITD and DNMT3A mutation status. (C) CIR in all patients with NPM1^mut, by FLT3-ITD and DNMT3A mutation status. (D) BM NPM1 MRD copy number (per 10⁵ copies ABL1) after each course of chemotherapy, by FLT3-ITD and DNMT3A mutation status. (E) Kaplan-Meier curve of OS in all patients with NPM1 mutant, by combined FLT3-ITD, DNMT3A, and WT1 mutation status.