Summary of patient treatment requirements according to both 2007 and 2022 blood staging criteria. More patients with 2022 B1 disease required tier 3 treatment (n = 12) compared with patients with 2007 B1 (n = 4). However, there were no significant differences in treatment requirements for 2007 B0 vs 2022 B0 (P = .96), 2007 B1 vs 2022 B1 (P = .55), and 2007 B2 vs 2022 B2 (P > .99). ECP, extracorporeal photopheresis; SCT, stem cell transplant.