Figure 1. Deletions of 2 α-genes giving... | American Society of Hematology

Figure 1.

Deletions of 2 α-genes giving rise to α0-thalassemia. Deletions that involve the ζ-globin gene (HBZ) are depicted in red. By far the most common α0-thalassemia deletion involved in Hb Bart’s hydrops fetalis (−−SEA deletion) is depicted in green. Bold lines indicate sequences known to be deleted. Thin lines indicate regions of uncertainty around the breakpoints. Reproduced with permission, with minor modifications, from Harteveld and Higgs.9

Deletions of 2 α-genes giving rise to α⁰-thalassemia. Deletions that involve the ζ-globin gene (HBZ) are depicted in red. By far the most common α⁰-thalassemia deletion involved in Hb Bart’s hydrops fetalis (−−^SEA deletion) is depicted in green. Bold lines indicate sequences known to be deleted. Thin lines indicate regions of uncertainty around the breakpoints. Reproduced with permission, with minor modifications, from Harteveld and Higgs.⁹

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