Combination receiver operating characteristic (ROC) curves from this study. (A-D) Combined ROC curves for different exocytosis stimulations (K562 cell stimulation for NK cells, anti-CD16 antibody for NK cells, and anti-CD3 antibody for CTL) when comparing 92 impaired exocytosis (EXO) patients against 4 other control groups consisting of 58 other IEI patients (A), 63 hyperinflammatory (HYPINF) patients (B), 198 healthy adults controls (C), or 84 healthy adults transport controls (D). Cutoff values with sensitivity and specificity are indicated in brackets for each comparison. (E-F) Plots show exocytosis values for different cytotoxic lymphocyte subsets and stimulations, as indicated. Each circle represents an individual patient color coded according to indicated key.