Enriched KEGG pathway analyses of mRNA data in CD20⁺ and T-cell subsets, respectively, confirm the association between CD163⁺ cell abundance and MAPK-upregulation in MCL TIMEs. To visualize the difference in gene expression between patients with MCL with CD163-rich and those with CD163-sparse TIMEs, enriched KEGG pathway analyses were performed based on differentially overexpressed genes in CD163-rich TIMEs in CD20⁺ cell segments (A), in CD3⁺/CD8⁺ cell segments (B), and CD3⁺/CD8^– cell segments (C).