CD163 and CD11c are independent prognostic markers in MCL. Multiplex IF staining of CD20, CD11c and CD163 was performed. (A) Examples of MCL TIMEs with either CD11c^low/CD163^high, CD11c^low/CD163^high, CD163^high/CD11^high, or CD11c^high/CD163^low (from left to right) are shown. (B) The prognostic value of CD11c, CD163, and p53 was investigated in univariate and multivariate Cox regression analyses. The Kaplan-Meier curve analysis and log-rank test showed the prognostic value of CD11c (C) and CD163 (D) as individual markers and the combined effect of CD11c and CD163 (E).