Markers of RBC physiology (OL cohort). Scatterplots for PoS (A), El_min (B), El_max (C), and (hyper) DRBCs (D) at BL and EOT. Each data point corresponds to data from 1 patient. Paired BL and EOT data points from each patient are connected by a line. Median BL and EOT values shown in green and blue diamonds, respectively. P values are from a Wilcoxon matched-pairs signed rank test. Percent hyper RBC is defined as the percent of RBCs with >41 g/dL of Hb. BL, baseline; DRBCs, dense RBCs; EI, elongation index; El_max, maximum EI; El_min, minimum EI; EOT, end of treatment; OL, open-label; PoS, point of sickling; RBC, red blood cell.