Systemic markers of SCD pathophysiology in patients with SCD (OL cohort). Each data point corresponds to data from 1 patient. Paired BL and EOT data points from each patient are connected by a line. Median BL and EOT values shown in green and blue diamonds, respectively. P values are from a Wilcoxon matched-pairs signed rank test. TNF-α (A), MMP-9 (B), leukocytes (C), prothrombin fragment 1.2 (D), D-dimer (E), and erythropoietin (F). BL, baseline; EOT, end of treatment; EPO, erythropoietin; FEU, fibrinogen equivalent unit; MMP-9, matrix metalloproteinase-9; OL, open-label; SCD, sickle cell disease; TNF-α, tumor necrosis factor alpha.