American Society of Hematology

Figure 4.

$Multiplex immunostaining to validate M1 and M2 polarization. In BL granulomatous cases, the fraction of macrophages was significantly high, with a lower density of M2/TAM polarized macrophages (A). Conversely, BL with starry sky pattern, both EBV+ (B) and EBV– (C) showed an higher density of M2 macrophages. Original magnification, ×40.$

Multiplex immunostaining to validate M1 and M2 polarization. In BL granulomatous cases, the fraction of macrophages was significantly high, with a lower density of M2/TAM polarized macrophages (A). Conversely, BL with starry sky pattern, both EBV⁺ (B) and EBV^– (C) showed an higher density of M2 macrophages. Original magnification, ×40.

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