Swimmer plot depicting targeted therapy outcomes. Patients are grouped by disease subtype. For each patient, targeted therapy is represented by horizontal bars, with the size of these bars proportional to the length of treatment, and the color representing the type of treatment. Targeted therapy was initiated at time point zero. To the left of the horizontal bars, best response on targeted treatment is summarized for each patient; when applicable, separately for multisystemic/solid lesions and neurodegenerative lesions. Within the bars, outcomes of radiologic response assessments are shown as colored rectangles. In the absence of radiologic response assessments, clinical responses are visualized as colored ovals. In general, the first assessment establishing a particular response (eg, a PR) is depicted. AXG, adult xanthogranuloma; BRAFi, BRAF inhibitor; H-UC, unclassifiable histiocytosis; HSCT, hematopoietic stem cell transplantation; JXG, juvenile xanthogranuloma; MS, multisystem; PEG-IFN-α, pegylated interferon-α.