Impact of EOI MRD status on EFS and OS. In terms of CR1 status, 3-year EFS was 68% (95% CI, 50-80) in EOI MRD-negative patients and 36% (95% CI, 19-53) in EOI MRD-positive patients (P = .012). Three-year OS was 84% (95% CI, 68-92) in EOI MRD-negative patients (n = 38) and 54% (95% CI, 30-67) in EOI MRD-positive patients (n = 29; P = .020).