FigureĀ 6.
Model of hTPO-hMPL-JAK2 axis pathway. (A) Map of patient mutations in the hMPL/hTPO/JAK2 complex. The patient mutations are highlighted by spheres. (B) Schematic depiction of the hMPL dimerization and activation, as well as JAK2 association and activation mechanism facilitated by TPO binding.