Epitopes of different anti-TF antibodies. FVII binds to the N- and C-modules of TF whereas FX binds to the C-module. Anti-TF antibodies can be divided into 2 groups: group 1 antibodies compete with FVII/FVIIa binding to TF via epitopes between amino acids 1 and 94; group 2 antibodies bind to TF (epitopes amino acids 136-214) as well as TF bound with FVII/FVIIa and all except 10H10 inhibit binding of FX and FIX. Professional illustration by Patrick Lane, ScEYEnce Studios.