Neuroanatomical differences between participants with HA and controls. (A) The model-derived standardized estimates for the group variable (x-axis) for each ROI (y-axis). The error bars represent 95% confidence limits. Estimates were adjusted for age. The black (vertical) line marks 0, or no significant effect of group on ROI. (B) The comparison of cerebellar GM volumes and hippocampal volumes between participants with HA and controls. Cerebellar GM volume (P = .049) and hippocampal volume (P = .073) were compared between the HA cohort and healthy controls, and were both demonstrated to be smaller in children with HA. Controls are shown in blue and participants with HA in red on the x-axis. The power-adjusted ROI (cerebellar GM or hippocampus) is on the y-axis. The open black circle represents the mean and error bars 95% CI. GM, gray matter; WM, white matter.