FigureĀ 4.
Open chromatin and enhancer mark profiles in the ETV6 neo-TAD region of patient and cell line samples. Open chromatin profiles (ATAC) of patients with AML , T1 and T2, and of HSPCs from ChiPSC22WT and ChiPSC22t(7;12) sublines 14D7, 23G8, and 24C7 in the ETV6 neo-TAD region. HSPC-specific enhancer mark H3K27ac and H3K4me1 profiles and publicly available10 p300, H3K27ac, and H3K4me1 profiles from MOLM-1 and CD34+. Relevant common peak positions are highlighted by a gray shading. The chr12 break point (BP) position in T1 and T2 and in the ChiPSC22t(7;12) sublines are indicated.

Open chromatin and enhancer mark profiles in the ETV6 neo-TAD region of patient and cell line samples. Open chromatin profiles (ATAC) of patients with AML , T1 and T2, and of HSPCs from ChiPSC22WT and ChiPSC22t(7;12) sublines 14D7, 23G8, and 24C7 in the ETV6 neo-TAD region. HSPC-specific enhancer mark H3K27ac and H3K4me1 profiles and publicly available10 p300, H3K27ac, and H3K4me1 profiles from MOLM-1 and CD34+. Relevant common peak positions are highlighted by a gray shading. The chr12 break point (BP) position in T1 and T2 and in the ChiPSC22t(7;12) sublines are indicated.

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