Directional permissive HLA-DPB1 mismatch subsets show differential associations with HCT outcome. (A) Cumulative incidences of grades 2 to 4 and 3 to 4 aGVHD, disease relapse, and NRM are plotted for HLA-DPB1 core permissive (yellow line) and noncore permissive (green line) mismatched pairs. P values indicated correspond to the univariable test of differential cumulative incidences between the 2 patient groups. Patients at risk at different time points are indicated for each group below each plot using the respective color coding. (B) Forest plots show the HR point estimates and 99% CI for grades 2 to 4 and 3 to 4 aGVHD, disease relapse, and NRM, and their associated P values from adjusted multivariable models. HLA-DPB1 permissive and nonpermissive mismatches were scored according to the core/noncore TCE model, in the GVH and HVG directions. Allele-matched patient-donor pairs are taken as reference. alloHCT, allogeneic HCT.