Platelet-associated gene expression is enriched in human AAA thrombi. RNA recovered from age-matched control aortic wall (n = 5), AAA aortic wall (n = 4), and AAA thrombi (n = 3) underwent RNA sequencing (RNA-seq). (A) Representation of principal component analysis of the RNA-seq results from control wall, AAA wall, and AAA thrombus samples. (B) Heat map of differences in gene expression in control wall, AAA wall, and AAA thrombus samples. (C) Heat map of platelet-associated transcripts in AAA thrombus vs AAA and control aortic tissue. (D) Volcano plot showing total fold change and P value of significant AAA thrombus genes vs AAA wall, with highlighted platelet-associated genes (red dots). (E) A list of the top 30 significantly enriched genes in AAA thrombus vs AAA wall; platelet-associated genes are bolded. PC, principal component (analysis); PF4, platelet factor 4.
Figure 1.

Platelet-associated gene expression is enriched in human AAA thrombi. RNA recovered from age-matched control aortic wall (n = 5), AAA aortic wall (n = 4), and AAA thrombi (n = 3) underwent RNA sequencing (RNA-seq). (A) Representation of principal component analysis of the RNA-seq results from control wall, AAA wall, and AAA thrombus samples. (B) Heat map of differences in gene expression in control wall, AAA wall, and AAA thrombus samples. (C) Heat map of platelet-associated transcripts in AAA thrombus vs AAA and control aortic tissue. (D) Volcano plot showing total fold change and P value of significant AAA thrombus genes vs AAA wall, with highlighted platelet-associated genes (red dots). (E) A list of the top 30 significantly enriched genes in AAA thrombus vs AAA wall; platelet-associated genes are bolded. PC, principal component (analysis); PF4, platelet factor 4.

This Feature Is Available To Subscribers Only

or Create an Account

Close Modal
Close Modal