JAK/STAT signaling in development of Dnmt3a-mutant T-ALL. (A) Engraftment levels of NICD-expressing Control (Ctl) or Dnmt3a^KO (3aKO) T-ALL cells in recipient mice before treatment with RUX or vehicle (veh) chow. (B) Kaplan-Meier plot of mice transplanted with control NICD-expressing cells treated with RUX or vehicle (veh) chow. (C) Kaplan-Meier plot of mice transplanted with Dnmt3a^KO NICD-expressing cells treated with RUX or vehicle (veh) chow. (D) Kaplan-Meier plot of mice transplanted with NICD-expressing cells of indicated genotypes with and without IL-6rα. (E) Kaplan-Meier plot of mice transplanted with NICD-expressing cells of indicated genotypes with and without Stat3. (F) Kaplan-Meier plot of mice transplanted with NICD-expressing cells of indicated genotypes with and without Stat5.