Time-series plots of PLTs (solid blue) and TLCs (dotted red) for 1 episode in 2 patients illustrating concordance in changes in counts. The observations indicated with a square do not belong to any domain because the data at these time points have their lagged PLTs (lag 1 PLT and lag 2 PLT) missing. The observations indicated with an open circle belong to the lower domain (with lagged percent change in PLT less than or equal to −0.00425), and with a solid circle belong to the upper domain.