VOD/SOS biomarker–based model stratification assuming baseline treatment values at AE = 2.5% and RRR = 40%. Preemptive treatment with defibrotide should be offered to patients who, according to the Cox or FFT model, have a predictive probability of SOS >6.25%. This occurs for each marker exceeding its cutoff∗ that is considered “positive” (see text for details). ∗The cutoffs for the markers are determined as 1100 ng/mL for L-ficolin, 200 ng/mL for hyaluronic acid, and 45 ng/mL for stimulation 2.