Mutational landscape of common T- and NK-cell neoplastic entities. Each column in the heat map represents a T/NK-cell neoplastic entity, and each row represents selected single nucleotide variants/indels and rearrangements (R), grouped according to functional annotations. The prevalence of mutations is color-coded, as shown in the legend. Genes with a mutational frequency of at least 10% observed in 1 or more mature T/NK-cell neoplasm were selected for display. Mutation frequencies 5%-10% were reported in some entities given their diagnostic or clinical value. ∗Refers to germ line mutation. BIA-ALCL, breast implant–associated ALCL; MF, mycosis fungoides; NK-LGLL, NK-large granular lymphocytic leukemia/chronic LPD of NK cells; pcALCL, primary cutaneous ALCL; SPTCL, subcutaneous panniculitis-like T-cell lymphoma; SS, Sezary syndrome; T-LBL, T-lymphoblastic leukemia/lymphoma; T-LGLL, T-cell large granular lymphocytic leukemia.