High SLFN11 expression correlates with increased OS in patients with AML. (A) Kaplan-Meier survival curves for patients with AML expressing high (above the median, n = 80) vs low (below the median, n = 81) SLFN11 expression. Data were extracted from the TCGA AML data set using the UCSC Xena browser. (B) Kaplan-Meier survival curves for patients with AML presenting (left) high (n = 65) vs low (n = 129) methylation levels at TSS 1500 of SLFN11 and (right) high (n = 130) vs low (n = 64) methylation levels at TSS 200 of SLFN11. Raw methylation data used in the MethSurv web tool were extracted from the TCGA AML data set available on the Broad Institute website. (C) Heat map showing the methylation levels of various CpG sites on SLFN11 in patients with AML. Data were extracted from the TCGA AML data set available on the Broad Institute website and graphed using the MethSurv web tool. CpG sites shown in panel B are highlighted in yellow. (A-B) Statistical analyses were performed using the log-rank test, and P values are shown. HR, hazard ratio; UTR, untranslated region.