Myocardial infarctions in patients with CVD enrolled in transfusion trigger trials. Relative risk of a MI (A) in individuals receiving a liberal vs restrictive transfusion trigger not undergoing cardiac surgery with preexisting CVD and hospitalized for ACS (top) or noncardiac reasons (bottom). Risk ratios of mortality and ACS were analyzed using random-effects models. All analyses were performed using R version 4.3.1 with package meta version 6.5-0. AMI, acute myocardial infarction; HCT, hematocrit; HgB, hemoglobin; PCI, percutaneous coronary intervention; RR, risk ratio. Adapted from Applefeld et al with permission.¹⁵