Comparison of outcomes in 9 transfusion trigger trials reporting myocardial infarction and death in patients with and without known CVD. (A) Mortality risk. ∗Restricitve vs liberal transfusion triggers had significantly different and opposite effect on mortality depending on the presence or absence of known CVD. In patients with known CVD, liberal strategies decreased mortality, and in patients without CVD, liberal strategies increased mortality. (B) Major acute coronary event. ∗∗In patients with known CVD as well as those without known CVD, there was a decrease in acute coronary events with a liberal transfusion strategy that overall was statistically significant. Adapted from Cortés-Puch et al with permission.²⁵