Example of rivaroxaban concentration-time profiles for each remedial strategy in patients remembering the missed dose after delaying for 8 hours. During the development of general module, the values of demographic covariates other than age, body weight, height, sex, renal function, and concomitant medications were fixed as the median values reported in the original literatures and could not be adjusted. The following parameters were set in this case: non-Asian male patient, age 60 years, body weight 70 kg, height 170 cm, serum creatinine 1 mg/dL, blood urea nitrogen 16 mg/dL, and without any potential comedication. The patient was prescribed with rivaroxaban 20 mg q24h. The minimum divided dose was set as 10 mg.