Figure 4.
Platelet transfusions alter plasma TRP metabolites in P yoelii infection. (A) Schematic diagram of platelet transfusion experimental set up (created with BioRender.com). (B) TRP and (C) KYN levels obtained from LC-MS/MS. (D) KTR as a measurement of IDO1 activity. (E) Serotonin quantification measured by ELISA, and (F) 5-HIAA levels obtained from LC-MS/MS (∗P < .05, ∗∗P < .01, ∗∗∗P < .001).

Platelet transfusions alter plasma TRP metabolites in P yoelii infection. (A) Schematic diagram of platelet transfusion experimental set up (created with BioRender.com). (B) TRP and (C) KYN levels obtained from LC-MS/MS. (D) KTR as a measurement of IDO1 activity. (E) Serotonin quantification measured by ELISA, and (F) 5-HIAA levels obtained from LC-MS/MS (∗P < .05, ∗∗P < .01, ∗∗∗P < .001).

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