scRNA-seq reveals the cellular constituents of the microenvironment of EMDs. (A) Uniform manifold approximation and projection (UMAP) plot calculated using the top 30 principal component analysis (PCA) components identified after batch correction for samples showing annotated cell types. (B) Normalized expression of marker genes used to annotate cell types. (C) Enriched pathways of each cell type, cross-referencing Kyoto Encyclopedia of Genes and Genomes (KEGG), MSigDB hallmarks, and WikiPathways databases with the top 50 upregulated genes for each cell type. (D) UMAP visualization depicting the annotated subclusters of T cells. (E) Density plot illustrating the expression of genes associated with T-cell dysfunction (PDCD1, LAG3, and HAVCR2) and T-cell function (GZMA, GZMB, and GNLY). NK, natural killer cells; NKT, natural killer T cells.