![ST reveals microenvironmental differences between therapy-responsive and therapy-resistant patients. (A-C) Leiden clustering of spots based on the cell type abundances for PT07 (A), PT08 (B), and PT10B (C). (D) Maximum-intensity projection (MIP) and transaxial [18F] fluorodesoxyglucose (FDG) positron emission tomography/computed tomography. The leftmost panels show PT07 at baseline and multiple lesions on both sides are indicated by arrowheads. In the middle panel, after talquetamab treatment, a follow-up scan was conducted 14 months later. A punch biopsy was taken from the lesion indicated by the circle. The rightmost panels display a follow-up scan after 20 months. Arrows indicate location of biopsied lesion. (E-G) Cell type abundances of PCs, macrophages M1, CD8+ T cytotoxic, and T-cells Tim3+ for PT07 (E), PT08 (F), and PT10B (G). (H) Cell type abundance comparing PCs, macrophages M1, and T-cells Tim3+ in all patients. Pairwise comparisons were implemented using the Wilcoxon test; ∗∗∗P < .001.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/144/20/10.1182_blood.2024024590/3/blood_bld-2024-024590-gr6.jpeg?Expires=1767789427&Signature=LTq~4UnBHX4yKcRac0fXmdpB4Ryb4TVtkoBvFNvpdwjyyWPrxmRL2z9yXZJ7VJbWNk811kzCBoG97p4leFhPLPzhiKnd-r8lplBuuNEN5WpSBgk~wpXXXFvSvNYuaY4AbfQgj-VYtht66LZQEHlDcUgoA0uS~V05xMisxAnauNS39JCjNhGtke6VdZN0IOdeWsiCl98TBTry~il5z~C8AE6YAOauwVksOTl8YzZJiBZZ-CV4K7QnzduqUZmiuBpO~TB1wYSTS~4gWyNxWWokso~Q2O76h6kr74cSiGU2vEteRrgCwrlKflosdCJVc2veu7QXIWFWo0vXn5bek0r7wQ__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
ST reveals microenvironmental differences between therapy-responsive and therapy-resistant patients. (A-C) Leiden clustering of spots based on the cell type abundances for PT07 (A), PT08 (B), and PT10B (C). (D) Maximum-intensity projection (MIP) and transaxial [18F] fluorodesoxyglucose (FDG) positron emission tomography/computed tomography. The leftmost panels show PT07 at baseline and multiple lesions on both sides are indicated by arrowheads. In the middle panel, after talquetamab treatment, a follow-up scan was conducted 14 months later. A punch biopsy was taken from the lesion indicated by the circle. The rightmost panels display a follow-up scan after 20 months. Arrows indicate location of biopsied lesion. (E-G) Cell type abundances of PCs, macrophages M1, CD8+ T cytotoxic, and T-cells Tim3+ for PT07 (E), PT08 (F), and PT10B (G). (H) Cell type abundance comparing PCs, macrophages M1, and T-cells Tim3+ in all patients. Pairwise comparisons were implemented using the Wilcoxon test; ∗∗∗P < .001.
