Figure 2.
CBX7 inhibitors reduce the viability of leukemic cell lines. (A) Chemical structure of EC compounds synthesized for this study. (B) Percentage viable OCI-AML3 cells normalized to their experimental untreated DMSO control after treatment with the EC compounds for 4 days. Data points are plotted as the mean of ≥3 replicates with SEM as error bar. (C) Percentage viable cells normalized to their experimental untreated DMSO control of 4 myeloid leukemia cell lines after treatment with increasing doses of the CBX7 inhibitors, MS452, EC-134, and BDA-41 for 4 days. Data points are plotted as the mean of ≥3 replicates with SEM as error bar. (D) IC50 values of each compound in the different cell lines are indicated in the heat map.
