B-cell reconstitution and cytokine evolution after R-CHOP therapy. Evaluation of absolute lymphocyte counts of CD45+ leucocytes (A), CD4+ T cells (B) and CD19+ B cells (C) during a 5-year follow-up. Proportions of naïve B cells (D), marginal zone-like B cells (E) and memory B cells (F) among the CD19 B-cell pool during a 5-year follow-up. Evolution of IL-6 (G), IL-10 (H), and BAFF (I) serum levels during a 5-year follow-up. Grey lines represend individual values and colored lines represent median values.