Impact of donor age. Waterfall plots of OS (A) and EFS (B) differentials based on predictions for the validation set. The OS and EFS differentials are noted on the vertical axis, with a zone of indifference denoted by the dashed gray horizontal lines at ±0.01, and predicted difference for each patient included in the validation set plotted along the x-axis. Differentials for an older donor vs an 18-year-old donor; donor ages (lines) are shown in ascending sequence: 21, 24, 27, 30, 31, 32, 33, 34, 37, and 40 years.