Sensitivity and linearity of coagulation assays to DOAC concentrations. Horizontal colored bars correspond to the approximate range of detectability of each assay (ie, sensitivity) below, within, and above expected on-therapy ranges. Diagonal hatching indicates linear relationship between coagulation assay and DOAC concentration within the range. Ranges are approximations and may vary based on assay, reagents, and analyzer. Adapted from Cuker et al. J Am Coll Cardiol. 2014;64:1128-1139.