Treatment options for LGL leukemia. AKT, protein kinase B; EPO, erythropoietin; ERK, extracellular signal-regulated kinase; GCSF, granulocyte colony-stimulating factor; HDAC, histone deacetylase; HMA, hypomethylating agents; IL, interleukin; IL-R, interleukin receptor; MEK, mitogen-activated protein kinase kinase; MIB1, Mindbomb E3 ubiquitin protein ligase 1; NFKB, nuclear factor-kappa B; PI3K, phosphoinositide 3-kinase; RANTES, regulated on activation, normal T cell expressed and secreted.