Suggested frontline treatment algorithm according to genetic CLL subgroups. Treatment is only indicated when iwCLL criteria of “active disease” are met.¹ Stratification is by 17p−/TP53mut (17p−: deletion 17p by fluorescence in situ hybridization; TP53mut: TP53 mutation by sequencing) and IGHV mutation status. Treatment options are prioritized from top (preferred options) to bottom (alternatives). The principal stratification by genetic factors must be put into context with patient comorbidities, comedications, preferences, and delivery-of-care aspects that may modify the preferred treatment choice.