Heat map of treatment options in rows and stratification factors in columns (genetic risk markers, therapy logistics, AE profiles, patient characteristics, and delivery-of-care aspects) weighed for pros and cons regarding treatment choice on a 5-tier scale (green most favorable, red most unfavorable) for typical patients with CLL (older adults and with comorbidities). Overall treatment preferences (3 columns on the left) are based on efficacy in genetic subgroups and modified based on therapy logistics (2 middle columns), AE profiles, comorbidities, and comedication (6 columns on the right).