Care delivery for acute pain in SCD. Optimizing care delivery practices influences clinical outcomes in acute SCD pain. Patients should have established individualized pain plans detailing the medications and dosing that have previously provided pain relief. Effective and comprehensive individualized pain plans often require multi-isciplinary collaboration with anesthesia/acute pain teams, psychology and/or psychiatry, pharmacy, physical therapy, integrative health, and child life. In the event of acute SCD pain, rapid analgesia (within 60 minutes of arrival) is critical to providing effective pain relief. The use of an individualized pain plan and day hospital/infusion center may facilitate rapid analgesia and avoid potential delays in EDs. Reassessments and repeated analgesia are recommended every 30 to 60 minutes. Ongoing multidisciplinary support for additional pain management and continuous adjustments to the individualized pain plan are needed.