Change in consolidation regime over time. (A) Stacked bar with proportion of consolidation approach by decade. There was significant change in consolidation with declining use of WBRT plus cytarabine (61% in 1990s vs 12% in 2010s) and rising use of AHCT (4% in 1990s vs 32% in 2010s) and cytarabine (27% in 1990s vs 52% in 2010s; Fisher exact test, P value <.001). (B) Consolidation approach in the 1980s stratified by RPA class. (C) Consolidation approach in the 1990s stratified by RPA class. (D) Consolidation approach in the 2000s stratified by RPA class. (E) Consolidation approach in the 2010-2020s stratified by RPA class.