Disposition of patients undergoing serial testing for CR, MRD status in the bone marrow and imaging and the outcome of patients in CR with imaging and MRD negative ≥5 years. (A) Workflow demonstrating systematic approach to definition of patients at our center with ≥3 consecutive MRD-negative years and concurrently in CR and imaging negative. (B) PFS of patients with MM at Icahn School of Medicine at Mount Sinai in CR with imaging and MRD negative ≥5 years from the start of their latest line of therapy. (C) Landmark analysis of PFS from the start of MRD negativity, according to different MRD-negative durations.