The HCD correlated with poorer outcomes in the PMBL LYSA cohort. (A) PFS and (B) OS according to clonal dominance status (assessed by 5′RACE) in the 5′RACE set from the PMBL LYSA cohort (n = 75). We identified a subset of 12 of 75 patients (16%) with the HCD (cutoffs: dominant clonotype representing >81.1% and >78.6% of all CDR3 sequences for IgVH and IgVL, respectively).