Duffy-null individuals show delayed ANC recovery after BCMA CAR-T. (A) Time to ANC recovery ≥1.5 × 103 cells per μL by Kaplan-Meier analysis for Duffy-null and Duffy non-null patients after BCMA-directed CAR-T therapy, with P value calculated by log-rank (Mantel-Cox) test and shaded confidence intervals shown for each curve. A total of 13 patients were censored before day 100 between the 2 groups, including 10 for disease progression (n = 2 Duffy-null), 1 for patient death (n = 1 Duffy-null), and 2 for end of available follow-up (n = 1 Duffy-null). (B) Mean ANC (×103/μL) at the start of lymphodepletion and at 30, 60, and 90 days after infusion in Duffy-null and Duffy non-null patients, with P values shown comparing groups by Welch's t-test. LD, lymphodepletion.
