Schematic representation of IKZF1-mediated gene regulation in B-cell development. IKZF1 primarily interacts with corepressors rather than coactivators. The KRK residues in the conserved helical motifs of IKZF1 mediate its interaction mainly with the NuRD complex. IKZF1 represses target genes by reducing chromatin accessibility and H3K27ac levels, particularly at enhancers rather than promoters.