Case examples. Demographic, clinical, and imaging measures are presented alongside angiography, T₁-weighted, T₂-FLAIR, and CBF images for 2 age-matched individuals with SCD and (A) VHS of 0 and (B) VHS of 2 on ASL MRI. The individual with VHS of 2 (B) had lower total Hb and arterial blood oxygen content; and displayed elevated CBF, reduced OEF, and reduced CMRO₂ compared with the individual with VHS of 0 (A). Orange arrows on panel B indicate evidence of signal hyperintensity in the superior sagittal sinus on ASL MRI.