Comparing cerebral hemodynamic measures in pediatric and adult participants separately. Box and violin plots are shown comparing (A) CaO₂, (B) gray matter CBF, (C) OEF, and (D) CMRO₂ between and within pediatric (n = 73) and adult (n = 70) participants. CaO₂, OEF, and CMRO₂ was significantly different across hyperintensity score in pediatric participants (CaO₂: P < .001; OEF: P = .046; CMRO₂: P = .033). Although statistically nonsignificant, we observe similar directionality in the adult participants. ∗P < .05; ∗∗P < .01; and ∗∗∗P < .001. n.s., not significant.