Distribution of EASIX and m-EASIX scores over time by CRS and ICANS severity, in pediatric and AYA patients treated with CD19-CAR T cells. Box plots of EASIX and m-EASIX score values (base-2 logarithm transformed) at days –5, 0, and +3 by severity of CRS (A-B) or ICANS (C-D). Asterisk (∗) indicates P < .05 from the univariate logistic regression between the log-transformed score and the onset of severe CRS or ICANS.