Biomarkers of disease progressions based on PET/CT values. (A) Univariate and multivariate analysis of TLG, MTV, and SUV_max with the presence of plasmacytomas. All values were considered as continuous, being analyzed for an association with the presence of plasmacytomas. For the multivariate logistic regression model, we included SUV_max, MTV, and TLG values. All 3 values were significant on the univariate model, but only MTV remained significant (P = .033) in the multivariate model. (B) ROC curve showing that MTV of 25 cm³ shows highest sensitivity (90.9%) and specificity (84%) for predicting plasmacytomas presence. All values were considered as continuous, being analyzed for an association with the presence of plasmacytomas. For the multivariate logistic regression model, we included SUV_max, MTV, and TLG values. All 3 values were significant in the univariate model, but only MTV remained significant (P = .033) in the multivariate model. (C) MTV of ≥25 cm³ at baseline PET/CT was associated with higher disease progression (D) and worst OS.