Histologic features of IDCH. Adult skin lesion (multifocal) with a dermal histiocytic infiltrate composed of cytoplasmic rich cells with (A) minimal nuclear folds and occasional Touton-like giant cells (hematoxylin and eosin), (B) an indeterminate cell immunophenotype including paranuclear cytoplasmic dot-like CD68 staining (CD68 PGM1 clone), (C) diffuse membranous CD1a (CD1a), and (D) negative Langerin/CD207 (CD207). The lesional infiltrate was negative for CD163 and Factor XIIIa but diffusely positive for S100 and fascin (not shown).

Histologic features of IDCH. Adult skin lesion (multifocal) with a dermal histiocytic infiltrate composed of cytoplasmic rich cells with (A) minimal nuclear folds and occasional Touton-like giant cells (hematoxylin and eosin), (B) an indeterminate cell immunophenotype including paranuclear cytoplasmic dot-like CD68 staining (CD68 PGM1 clone), (C) diffuse membranous CD1a (CD1a), and (D) negative Langerin/CD207 (CD207). The lesional infiltrate was negative for CD163 and Factor XIIIa but diffusely positive for S100 and fascin (not shown).

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