In vitro efficacy of BCL2 and BCL2/BCL-XL inhibition in panel of B- and T-ALL cell lines and PDX models. Cells were tested for the inhibitory effect of the BCL2/BCL-XL dual inhibitor AZD4320 compared with that of the selective BCL2 inhibitor venetoclax. Cell viability and apoptosis were evaluated, followed by 24 hours incubation with indicated drug concentrations and measured by CellTiter-Glo and annexin-V assays. Results were summarized and presented separately for (A-B) B-ALL cell lines, (C-D) PDX B-ALL models, (E-F) T-ALL cell lines, (G-H) PDX T-ALL models, and (I-J) Ph-like B-ALL cell lines. All calculations were performed using GraphPad prism statistical software version 9.

In vitro efficacy of BCL2 and BCL2/BCL-XL inhibition in panel of B- and T-ALL cell lines and PDX models. Cells were tested for the inhibitory effect of the BCL2/BCL-XL dual inhibitor AZD4320 compared with that of the selective BCL2 inhibitor venetoclax. Cell viability and apoptosis were evaluated, followed by 24 hours incubation with indicated drug concentrations and measured by CellTiter-Glo and annexin-V assays. Results were summarized and presented separately for (A-B) B-ALL cell lines, (C-D) PDX B-ALL models, (E-F) T-ALL cell lines, (G-H) PDX T-ALL models, and (I-J) Ph-like B-ALL cell lines. All calculations were performed using GraphPad prism statistical software version 9.

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