Prosurvival protein dependency in primary T-ALL in vitro. (A) The correlation of drug sensitivity expressed as area under drug response curve (AUC) for navitoclax, AZD4320, and AZD5991 in select samples from patient with ALL. (B-C) Correlative studies on gene activity and drug sensitivity for select gene/inhibitor pairs. The statistical differences between treatments conditions were evaluated using unpaired Student t tests; P and R values are indicated on individual figure panels. All calculations were performed using GraphPad prism statistical software version 9.