Schematic of the effects and timing of the application of different coordNum CVs used to induce binding between major domains in the EC during the first 150 nanoseconds of the simulation. TF is shown in blue, FVIIa in orange, and FX in purple, with major domains labeled. Arrows are used to show when the CVs were active to control the movement of the domains. Large arrows indicate a distance CV, whereas small arrows indicate a contact CV.